Professor Karpowitz is married to Jordan Ensign Karpowitz, and together, they have four terrific children — Caleb, Quinn (married to Michayla), Camille, and Zachary — and two practically perfect grandchildren. Though the family spent no time in Lake Wobegone, all their children are above average. ┬áThe oldest of six children, Professor Karpowitz grew up in Lawrence, Kansas and has maintained a lifelong loyalty to his hometown Kansas Jayhawks basketball team.

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